Entries Tagged 'Science' ↓

In a review written by well-known neuroscientist Roger Tsien and his colleagues, Clontech was mention as “(f)or example, the newly released DsRed-Monomer (Clontech) is described as “bright,” even though in fact, it is the dimmest monomeric red fluorescent protein (RFP) presently available.”

Unfortunately, the review is titled “A guide to choosing fluorescent proteins” (doi:10.1038/nmeth819, the review is subscription required).

Mate choice decisions: the role of facial beauty in Trends in Cognitive Sciences

Now I’m really curious what is the theory for looking at boobs. Any idea, or what I really want, peer-reviewed papers?

他的实验室把一个参与 RNA interference 的蛋白命名为 R2D2，另一个则险些成为 C3PO。看看 PNAS 上他的 profile。

Fluorescence microscopy by Jeff W Lichtman & José-Angel Conchello

Is string theory in trouble? at NewScientist.com.

I just began to read The Elegant Universe, and this news spoiled my interest in the book a little bit.

缺钱成为各种生物信息学数据库的最大问题。最近蛋白质相互作用数据库 BIND.ca 关闭。下面是网站负责人贴出的通告：

16 November 2005

Important Notice Regarding BIND Curation and Web Services.

(c) 2005 Christopher Hogue. Reproduction without Permission is Prohibited.

As of today the Blueprint Initiative has fully expended available core funding in both Canada and Singapore.

No further funding is available at this time, and as a result, Biomolecular Interaction Network Database (BIND) curation activities has been terminated. Journals and partners have already been notified of this change.

Remaining Blueprint Initiative staff members are making every effort to implement the BIND curation wind down in an orderly manner, and to maintain web servers and services in a stable state. Response to info e-mail queries and to user-submissions to the BIND database will be limited or delayed due to staffing shortages.

As Principal Investigator of The Blueprint Initiative I would like to thank my host institution Mount Sinai Hospital, my Scientific Advisory Board and my entire research team who delivered on the Blueprint Initiative’s promise. I would also like to thank historic Blueprint Initiative funding agencies, partner institutions, collaborators and commercial sponsors who are listed at blueprint.org.

With extraordinary on-going support from Mount Sinai Hospital in Toronto, Ontario, Blueprint Initiative products and services such as BIND and the data warehouse SeqHound along with many other resources will continue to be made freely available on an open access basis.

Finally, I would like to reiterate my conviction that public databases are essential requirements for the future of life sciences research. The question arises will these be free or will they require a subscription. Should BIND/Blueprint be sustained as a public-funded open-access database and service provider?

Feel free to write me at chogue@blueprint.org with your thoughts.

Yours sincerely,

Christopher W.V. Hogue, Ph.D.

My BLOG on Bioinformatics. http://bioimplement.blogspot.com/

P.S.

You may read more about the global issue of sustainable public funding for public life-sciences database in the following articles and web sites (reprinted with permission).

OECD Declaration on Access to Research Data from Public Funding:

Coverage in Science: OECD_science_paper.pdf

The OECD Declaration (Annex 1)

CODATOECD Follow-Up Group Document

The Problem of Sustainable Database Funding, Coverage in:

BioInform: bioinform_funding_article.pdf

Nature: Nature_Database_funding_062305.pdf

Nature Biotechnology: NatBiotech_16_1323.pdf

Nature Cell Biology: NatCellBiol_7_639.pdf

Nature Structural & Molecular Biology: NatStructMolBiol_12_633.pdf

Both Sides of the Canadian Co-Funding Issue:

Genome Canada: Co-funding

Arthur Carty, Scientific Advisor to the Prime Minister in Science: SCIENCE letter

Canadian Society of Biochemistry, Molecular and Cellular Biology Petition: Petition

在PubMed上搜索，然后通过点击各种链接最后获得那个PDF文件是我们每天的工作。实在是无聊啊。今天终于看到解决这个问题的软件了。QUOSA。“If you regularly use PubMed, OVID, Google Scholar, or other scientific journal “gateways” , then QUOSA can save you a lot of time.”

就是太貴。Student 还要$125.

Popular Science2005年度的Best of What’s New，里面有不少好玩的东西。譬如，彩色肥皂泡。

[From: [ i D | 公 社]

Action Potential is written by Nature neuroscience editors.

老鼠是可以发出高频声响的,不过人类听不到。现在有人对老鼠的这些高频声音进行了分析发现这些声音是有规律的，也就是说：“老鼠也唱歌。”

论文发表在：PLos Biology — Ultrasonic Songs of Male Mice

SciAme的报道。

老鼠“唱”的歌可见：

Plos Biology 和 SciAme